The defending champions were humbled 10-30 in the opening round last Sunday at Racing, but they have brought in some of their big names to get their campaign up and running at the second attempt.
Three players who featured in the final in Yokohama against South Africa on November 2 are in the starting XV. They included the debut-making Elliot Daly, who slots in at full-back after making the summer switch from Wasps.
In total, Mark McCall has changed seven of his starting side following the defeat in Paris in a week where Saracens decided not to appeal their 35-point deduction and £5.3million fine for breaching the Premiership salary cap.
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There is a fresh look to the front row replacements as George, Richard Barrington and Josh Ibuanokpe are selected following international duty, injury and suspension respectively while academy back row Andy Christie could earn a debut run out in European club rugby’s blue-riband competition.
SARACENS (v Ospreys, Saturday)
15 Elliot Daly; 14 Rotimi Segun, 13 Duncan Taylor, 12 Brad Barritt (capt), 11 Alex Lewington; 10 Manu Vunipola, 9 Tom Whiteley; 1 Mako Vunipola, 2 Jack Singleton, 3 Titi Lamositele, 4 Will Skelton, 5 George Kruis, 6 Nick Isiekwe, 7 Ben Earl, 8 Jackson Wray. Reps: 16 Jamie George, 17 Richard Barrington, 18 Josh Ibuanokpe, 19 Joel Kpoku, 20 Andy Christie, 21 Richard Wigglesworth, 22 Alex Lozowski, 23 Matt Gallagher.
WATCH: The Rugby Pod gives its reaction to Saracens not appealing the 35-point deduction and fine for breaching Premiership Rugby salary cap regulations
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