George missed the 27-22 defeat by Ireland in Dublin due to a hamstring strain.
The enduring class of Taulupe Faletau, Liam Williams and Josh Adams on their returns gives Wales hope after a wretched year.
Last weekend’s defeat to New Zealand was England’s fifth reverse in seven outings, but a three wins from four Autumn Nations Series can still quieten Borthwick’s critics.
Following four seasons at Perpignan, the 32-year-old versatile back was signed by Toulouse last summer, but he never got to play for them.
Star wing has left a void for club and country.
The undefeated Chiefs have been the form team of Super Rugby Pacific this season, but they face another tough test against title holders the Crusaders on Saturday.
Freddie Steward insists England face their moment of truth when they attempt to begin the healing process against Grand Slam-chasing Ireland in Dublin on Saturday.
The Crusaders have announced that former All Blacks George Bridge has played his final game in the red and black jersey and will soon take up a contract with French club Montpellier.