Tuilagi made his international comeback off the bench against Australia last November and will make up the centre pairing with Henry Slade in Dublin on Saturday, with Ben Te’o ruled out due to a side strain.
Elliot Daly gets the nod at full-back as Brown is overlooked, with Owen Farrell captaining the side at fly-half.
BREAKING | Your England team to face Ireland on Saturday in the #GuinnessSixNations
— England Rugby (@EnglandRugby) January 31, 2019
England: Elliot Daly, Jonny May, Henry Slade, Manu Tuilagi, Jack Nowell, Owen Farrell (captain), Ben Youngs; Mako Vunipola, Jamie George, Kyle Sinckler, Maro Itoje, George Kruis, Mark Wilson, Tom Curry, Billy Vunipola.
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