In the front row, Dylan Smith and Malcolm Marx both drop down to the bench with Jacques van Rooyen and Robbie Coetzee taking their places in the starting side. Ruan Dreyer takes over at tighthead in place of Jacobus Adriaanse.
Marvin Orie shifts to the No. 4 jersey and he will be partnered by Franco Mostert in the second row.
There is also a new-look back row. Albertus Smith shifts to No. 8 and Robert Kruger and Cyle Brink are the two flankers in the starting side.
Sylvian Mahuza returns to the right wing after a week off.
For the Jaguares, Mario Ledesma has made two changes to his starting side that were defeated by the Reds last weekend.
Felipe Arregui will start the game on the bench and Santiago García Botta will be wearing No. 1 jersey in the front row.
In the backline, Bautista Ezcurra comes into the midfield to replace Santiago González Iglesias.
Meanwhile, Juan Martín Hernández will not be available for the game and his place on the bench will be occupied by Jerónimo de la Fuente.
15. Joaquin Tuculet, 14. Bautista Delguy, 13. Matias Orlando, 12. Bautista Ezcurra, 11. Emiliano Boffelli, 10. Nicolas Sanchez, 9. Gonzalo Bertranou, 8. Javier Ortega Desio, 7. Marcos Kremer, 6. Pablo Matera (C), 5. Tomas Lavanini, 4. Matias Alemanno, 3. Nahuel Tetaz Chaparro, 2. Agustin Creevy, 1. Santiago Garcia Botta.
Replacements: 16. Julian Montoya, 17. Felipe Arregui, 18. Juan Pablo Zeiss, 19. Guido Petti, 20. Juan Manuel Leguizamon, 21. Martin Landajo, 22. Jeronimo de la Fuente, 23. Ramiro Moyano.
15. Andries Coetzee, 14. Sylvian Mahuza, 13. Lionel Mapoe, 12. Rohan Janse van Rensburg, 11. Aphiwe Dyantyi, 10. Elton Jantjies, 9. Marco Jansen van Vuren, 8. Albertus Smith, 7. Robert Kruger, 6. Cyle Brink, 5. Franco Mostert, 4. Marvin Orie, 3. Ruan Dreyer, 2. Robbie Coetzee, 1. Jacques van Rooyen.
Replacements: 16. Malcolm Marx, 17. Dylan Smith, 18. Johannes Jonker, 19. Lourens Erasmus, 20. Len Massyn, 21. Dillon Smit, 22. Howard Mnisi, 23. Shaun Reynolds.
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