Italy and Argentina have both named sides with only two players with fewer than 10 caps for their encounter in Udine on Saturday.
South Africa clinched the Rugby Championship in emphatic style with a bonus-point win over Argentina at the Mbombela Stadium in Nelspruit on Saturday.
Argentina player ratings: The Los Pumas didn't show too much in their defeat to the Springboks in the Rugby Championship decider in South Africa.
Argentina head coach Felipe Contepomi has made seven changes to the team that triumphed over South Africa last week for their rematch in the final round of The Rugby Championship on Saturday.
Argentina completed a superb comeback to keep their hopes of a Rugby Championship title alive with a 29 - 28 victory over the Springboks.
Argentina handed Australia a record defeat 67 - 27 in Santa Fe for one of the very best performances ever from a Pumas side.
Academy graduate Matthew Devine impressed as Connacht blitzed Zebre 54-16 in the United Rugby Championship at Dexcom Stadium.
The Welsh region began slowly but two breakaway tries in quick succession gave them increased confidence to dominate the game.