Can England arrest their late woes, Wales emerge from the darkness and Italy continue rising high?
Should Joe Schmidt step aside after the Lions tour, is there a home-grown coach ready to take on the full weight of responsibility?
With no evidence of progress and 400 days since Wales' last win, Warren Gatland is under intense scrutiny.
Gareth Davies will captain Wales against the Reds after Cory Hill's late withdrawal moments before kick-off for personal reasons.
Grace scored 89 tries for St Helens in his league career.
Taine Plumtree will start in the No. 8 jersey for just the second time in his young Test career.
Cardiff flanker Ellis Jenkins has tipped his teammate, 20-year-old Mackenzie Martin, to be one of the leading contenders to take the No8 jersey from Taulupe Faletau for both club and country.
The Welsh lost out 7-31 at Aviva Stadium on February 24 and they now go in against the French at Principality Stadium with an entirely changed midfield and two more alterations in their pack.