Mako Vunipola misses England's match against Ireland as the prop flies back to Tonga for 'family reasons'
Vunipola has been left out of the 33-man training squad that will prepare for the round three fixture, with Beno Obano called up in his place.
Losing Vunipola is a major blow for England, who have already lost his younger brother Billy to a broken arm for the entire Six Nations.
Eddie Jones still has two high-quality looseheads at his disposal, however, in Joe Marler and Ellis Genge.
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Luke Cowan-Dickie (Exeter Chiefs)
Tom Curry (Sale Sharks)
Tom Dunn (Bath Rugby)
Ben Earl (Saracens)
Charlie Ewels (Bath Rugby)
Ellis Genge (Leicester Tigers)
Jamie George (Saracens)
Maro Itoje (Saracens)
George Kruis (Saracens)
Joe Launchbury (Wasps)
Courtney Lawes (Northampton Saints)
Lewis Ludlam (Northampton Saints)
Joe Marler (Harlequins)
Beno Obano (Bath Rugby)
Kyle Sinckler (Harlequins)
Will Stuart (Bath Rugby)
Sam Underhill (Bath Rugby)
Harry Williams (Exeter Chiefs)
Elliot Daly (Saracens)
Ollie Devoto (Exeter Chiefs)
Fraser Dingwall (Northampton Saints)
Owen Farrell (Saracens)
George Ford (Leicester Tigers)
George Furbank (Northampton Saints)
Willi Heinz (Gloucester Rugby)
Jonathan Joseph (Bath Rugby)
Jonny May (Leicester Tigers)
Henry Slade (Exeter Chiefs)
Ollie Thorley (Gloucester Rugby)
Manu Tuilagi (Leicester Tigers)
Jacob Umaga (Wasps)
Ben Youngs (Leicester Tigers)
Alex Mitchell (Northampton Saints)
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