It is the second time in the space of six days that injury has prevented the 27-year-old from making his England debut.
But he missed the 33-19 victory against Wales at Twickenham with a hip problem.
TEAM UPDATE | Ruaridh McConnochie has been withdrawn from the squad today due to a minor muscle strain and will be replaced on the right wing by Anthony Watson.
— England Rugby (@EnglandRugby) August 17, 2019
The winger is a sevens specialist who won a silver medal with Great Britain at the 2016 Olympics in Rio de Janeiro.
Bath team-mate Watson made his comeback from a serious Achilles injury in last weekend’s win.
– Press Association
WATCH: Wales boss Warren Gatland talks to the media ahead of Saturday’s match in Cardiff
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