Johann van Graan has selected a completely different pack to the one that started the 61-26 thrashing of Gloucester in last Sunday's Challenge Cup quarter-final for this weekend's trip to Exeter.
Scotland playmaker Finn Russell will be hoping to show the sort of form that helped beat Challenge Cup quarter-final opponents Gloucester in the Premiership last month.
Leaders Bath maintained their imperious form in the Gallagher Premiership with a 47-28 victory over Harlequins in front of another sell-out crowd at the Recreation Ground.
England lock Ollie Chessum will return to Leicester Tigers' starting XV on Sunday as his side host Saracens in the Gallagher Premiership.
England captain Maro Itoje will return to captain a Saracens side containing four of his international team-mates during the Guinness Six Nations when they host Harlequins in the Gallagher Premiership on Saturday.
The current strength of the Premiership does not warrant eight of its 10 clubs being involved in Europe's elite tournament.
Bath player ratings: In tough conditions at The Rec, Bath battled bravely but ultimately fell to a disappointing 24-20 Investec Champions Cup defeat to La Rochelle.
Ronan O'Gara has laid to rest any concerns that he may rest some of his La Rochelle stars for their opening match of the Investec Champions Cup by naming a formidable outfit to run out at Bath's Rec on Friday.
Max Ojomoh is in line to make his first appearance of the season for Bath after recovering from the foot injury he sustained in the pre-season friendly against Ealing Trailfinders.