Newcastle bring props Adam Brocklebank and Mark Tampin and winger George Wacokecoke into their line-up as they look to build on last week’s seven-try triumph over London Irish.
Northampton hung on with 14 men in the closing stages to clinch a typically hard-fought Premiership derby against Leicester.
Northampton Saints have been forced into three late changes ahead of their Derby match with Leicester Tigers.
Karl Wilkins was 18 when he decided to embark on a French adventure that has now ended with him coming back to Northampton all grown up.
Exeter boss Rob Baxter had no complaints about a dramatic finale at Sandy Park after his Gallagher Premiership champions were beaten 13-12 by Northampton.
Stuart Hogg and Exeter were left furious with how their defeat to Northampton ended with a charged-down conversion attempt.
Northampton won their third Premiership match on the bounce on Saturday but the majority of the performance was rubbished by Chris Boyd.
Wasps crashed to a second home defeat in succession as resurgent Northampton won 22-17 to collect a third consecutive Gallagher Premiership win.
All of the starting line-ups for the Gallagher Premiership Round Four action this Boxing Day and Christmas weekend.
Chris Boyd said he would likely send a much-changed Northampton XV to Leinster and that is what he has done despite a 12-game losing streak.