Fly-half Allan will wear 10 at international level for the first time since facing Canada last June, with Carlo Canna dropping to the bench.
Centre Campagnaro also gets his chance at the expense of Tommaso Benvenuti, who has been named among the replacements for the clash against the defending champions and leaders at Twickenham.
Giulio Bisegni comes back in on the right wing, with Angelo Esposito dropping out of the squad, and Abraham Steyn has been restored to the back row in place of Maxime Mbanda.
Dario Chistolini was ruled out due to injury this week, so Michele Rizzo takes his place on the bench along with Pietro Ceccarelli as Italy looked to put up more of a fight then they did in a 63-10 hammering against Ireland in Rome last time out.
Italy: Edoardo Padovani, Giulio Bisegni, Michele Campagnaro, Luke McLean, Giovanbattista Venditti, Tommaso Allan, Edoardo Gori; Andrea Lovotti, Leonardo Ghiraldini, Lorenzo Cittadini, Marco Fuser, Dries Van Schalkwyk, Abraham Steyn, Simone Favaro, Sergio Parisse (captain).
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