The 27-year-old prop, capped 51 times by England, suffered a calf strain in his club’s European Champions Cup loss to Glasgow Warriors on Sunday and Sarries confirmed he will be sidelined for “around six weeks”.
Jones’ side have four November games at Twickenham against South Africa, New Zealand, Japan and Australia but England have been hit by a spate of long-term injuries.
Billy Vunipola, Mako’s brother, is out due to a fractured arm suffered in the same game his younger sibling sustained his problem.
? | Mark McCall has confirmed Mako Vunipola and Nick Isiekwe will be out of action for around six weeks and eight weeks respectively. pic.twitter.com/huQo7w3Obs
— Saracens Rugby Club (@Saracens) October 17, 2018
Sign up to our mailing list for a weekly digest from the wide world of rugby.Sign Up Now