The wing has 51 international caps but has not appeared for his country since a defeat to South Africa 12 months ago.
He will replace Damian Penaud after the left wing sustained an ankle injury in the first half of the loss to the Springboks last weekend.
In the other change to the French team, Gael Fickou will replace Geoffrey Doumayrou at inside centre.
France, who will be captained by Guilhem Guirado, have lost five games in a row and have not been defeated in six successive matches since a 10-game losing streak in 1968-69.
???? Relever la tête. Repartir de l'avant ! Voici la composition du #XVdeFrance pour affronter samedi à 21h l'Argentine @lospumas au @StadePM de @lillefrance ! #NeFaisonsXV #FRAARG pic.twitter.com/PWrM3iYdbd
— FF Rugby (@FFRugby) November 15, 2018
Argentina’s team features just one change, with scrum-half Gonzalo Bertranou replacing Tomas Cubelli.
Bertranou did not feature in the recent loss to Ireland but has otherwise been a regular for the Pumas this year.
France: Maxime Medard, Teddy Thomas, Mathieu Bastareaud, Gael Fickou, Yoann Huget, Camille Lopez, Baptiste Serin; Jefferson Poirot, Guilhem Guirado, Cedate Gomes Sa, Sebastien Vahaamahina, Yoann Maestri, Wenceslas Lauret, Arthur Iturria, Louis Picamoles.
Replacements: Camille Chat, Dany Priso, Rabah Slimani, Paul Gabrillagues, Mathieu Babillot, Antoine Dupont, Anthony Belleau, Benjamin Fall.
Argentina: Emiliano Boffelli, Bautista Delguy, Matias Orlando, Jeronimo de la Fuente, Ramiro Moyano, Nicolas Sanchez, Gonzalo Bertranou; Santiago Garcia Botta, Agustin Creevy, Santiago Medrano, Matias Alemanno, Tomas Lavanini, Pablo Matera, Guido Petti, Javier Ortega Desio.
Replacements: Julian Montoya, Juan Pablo Zeiss, Lucio Sordoni, Mariano Galarza, Rodrigo Bruni, Tomas Lezana, Tomas Cubelli, Matias Moroni.
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