The full-back has not played since suffering a head injury in Wales’ victory over Australia in November.
Halfpenny has been cleared to return at Parc y Scarlets, where he will look to prove he can play a part in the final two rounds of the Six Nations after the clash with England on Saturday came too soon.
Fellow Wales international Rhys Patchell, who recovered from a hamstring injury to face Benetton, once again has to settle for a place on the bench.
Wyn Jones, Ryan Elias and Jake Ball are another trio of Wales players who will feature for Wayne Pivac’s side.
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