Iain Henderson has been ruled out the Guinness Six Nations match against England on Sunday for family reasons.

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Having featured off the bench against Scotland and Wales, Devin Toner will start the game in London and win his 70th cap.

Ultan Dillane comes into the replacements. He last featured for Ireland in last season’s 26-14 win against France at the Aviva Stadium.

Toner’s revival under Andy Farell has been popularly received after the long-serving second row was axed by Joe Schmidt for the World Cup in Japan to accommodate project player Jean Kleyn.

Farrell had initially named an unchanged starting team for Twickenham following the round two win over Wales, keeping faith with the XV that win 24-14 and making only a single alteration to the bench where Caelan Doris came in for Max Deegan.

Rookie Doris earned his debut cap when starting the championship opener versus Scotland but he was concussed in the opening minutes, allowing Peter O’Mahony to come off the bench and reclaim the starting spot he had lost to the young Leinster back row.

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WATCH: Andy Farrell is confident ahead of the trip to England

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