Scarlets powerhouse Ball was carted off in the first half of a 33-18 defeat to New Zealand last weekend and will undergo surgery to repair the damage.
Tipuric suffered a quad injury in the loss to the world champions and the back-row has been released from the squad to be treated by Ospreys.
Wales also have an injury concern over scrum-half Rhys Webb, who is going through concussion protocols after taking a blow to the head against the All Blacks.
Thanks for all the support and messages over the last couple days much appreciated. Best of luck to the @WelshRugbyUnion lads this weekend
— Jake Ball (@Jake_Ball4) November 28, 2017
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