Wales will aim to harness the passion of their home crowd but the game will be decided by form, not historical enmity, with England in pole position.
Can England arrest their late woes, Wales emerge from the darkness and Italy continue rising high?
Wales finished their latest Autumn Nations Series campaign last Saturday with a thud, their 45-12 loss to the Springboks with Gatland in charge setting a new record low of 12 defeats in a row.
With no evidence of progress and 400 days since Wales' last win, Warren Gatland is under intense scrutiny.
The former rugby league star is looking to impress after switching codes.
The ball-playing Ospreys loosehead is finding his voice as a leader he prepares to take on the fearsome Springboks pack
Rees-Zammit’s rugby union career comes to a halt after winning 32 Wales caps.
Wales are gearing up for their tournament opener against Scotland on February 3.
How many fresh faces who have caught the eye this season can we expect to see picked by Warren Gatland?
Rob Howley will be back in the Wales senior men’s camp for the 2024 Guinness Six Nations, but not before he has taken a lead role with the Wales U20s side as they prepare for their own Championship campaign.