Munster picked up a signature Champions Cup win as they downed Saracens 17 - 12 in an old school tussle at Thomond Park.
There is no return for O’Mahony, whose last appearance came in the December 13 defeat at Castres.
Caelan Doris has been named Ireland captain for the Autumn Nations Series, taking over from Peter O'Mahony who has also been named in the squad.
Veteran scrum-half Conor Murray has returned home to Ireland midway through Munster's tour of South Africa for personal reasons.
Munster player ratings: Munster lost 26 - 12 to rivals Leinster in front of a league record 80,000-plus fans at the iconic Croke Park stadium in Dublin.
Leo Cullen’s unbeaten URC table-toppers defeated Benetton 35-5 last weekend in Italy and they have altered their line-up with two changes in the pack and one in the backs.
Zebre Parma made history by securing their first-ever victory over Munster with a 42-33 bonus-point win in the United Rugby Championship.
New signing Billy Burns is set to make his Munster debut against Bath later today in a pre-season friendly at The Rec.
Warriors will be rank outsiders in Pretoria but there are parallels with their title-winning vintage of 2015.