The South African-born centre was forced off in the first half of Saturday’s 50-27 win over Bath at Allianz Park after catching a boot to the face in a tackle.
The former England international saw a consultant after the match to discover the extent of the damage and will have surgery this week, ruling him out for the Quins match at the Twickenham Stoop.
Saracens, the defending Premiership champions, have made a blistering start to the season winning all five matches, taking maximum points in the process and sit top, a point ahead of Exeter Chiefs.
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