Leinster are set to give Wallaby powerhouse Joe Tomane his first start as a Leinster player against ProD2 opposition.
Ireland thrashed Japan 50-22 in the series opener and Joe Schmidt has made six changes for this weekend's meeting.
An 18-point shutout away win – courtesy of second-half Caelan Doris and James Tracy tries - confirmed Leo Cullen's record-breaking Leinster as top seeds for the Champions Cup knockout stages.
Leinster came good in the second half to claim a crucial 24-12 Guinness PRO14 bonus-point win over previously-unbeaten Ulster.
Leinster have rung 13 changes to their starting XV after last weekend's loss, but retention of Johnny Sexton means a new role for Ross Byrne.
Ryan Baird is to set to start at six for Leinster, as Leo Cullen looks to run the positional experiment denied to him by the cancellation of Leinster and Munster's St Stephen's Day derby.
Leinster were set to switch up the position of highly-rated second row Ryan Baird for their now postponed clash against Munster.
Leinster got their Heineken Champions Cup campaign off to a perfect start with a five-try win in Montpellier.