Leinster have rung 13 changes to their starting XV after last weekend's loss, but retention of Johnny Sexton means a new role for Ross Byrne.
His only previous Test start - an Ireland hammering at Twickenham - cost Ross Byrne an RWC squad place but he is backed for a happier return.
Amid doubts about the availability of Joey Carbery for the start of Ireland's World Cup, Joe Schmidt is set to give a first Test start to Ross Byrne.
Putting his French contacts to good use, Lee Byrne dismisses claims of rancour in the French camp and warns that Wales must be switched to deliver a quarter-final win.
Leinster are five points clear at the top of Conference B after the defending champions beat Munster at the Aviva Stadium.
Ireland captain Sexton cut an annoyed figure at being replaced by Ross Byrne in the final quarter of his side’s galling defeat at the Stade de France.
Joey Carbery's injury has exposed the lack of experience at out-half in the Ireland squad beneath Johnny Sexton and fans are split on whether Ross Byrne or Jack Carty should go to RWC.
Bryan Byrne's late try and Ross Byrne's subsequent conversion saw champions Leinster snatch victory over Cardiff Blues in the Pro14.