Morgan Parra and Brice Dulin suffered injuries in European Champions Cup matches at the weekend, ruling them out of France's Ireland clash.
Dimitri Yachvili has no doubt Baptiste Serin can be a star at scrum-half for France for years to come.
France will be looking to the inexperienced Baptiste Serin to pull the strings at Twickenham in only his third start for his country.
The blunder occurred as Vakatawa casually jogged into the in-goal, failing to put the ball down quickly as Toulon winger Gabin Villiere snuck up behind him.
France have been fastest out of the blocks ahead of the 2021 Six Nations, naming a 37-strong squad that contains three newcomers.
Vision of Springbok lock Eben Etzebeth getting into an altercation with his Toulon teammate while warming up before a Top 14 game has surprised even South African supporters.
Toulon secondrow Eben Etzebeth failed to return to the field after sustaining a head injury playing for the French side in their Heineken Champions Cup victory over Sale Sharks.